Medical biochemistry, molecular and cell biology III lectures

Date, time, location

Wednesday 10:55-12:05 Szent-Györgyi Albert Lecture Hall
Friday 08:00-09:10 Szent-Györgyi Albert Lecture Hall

 

EOK-Building, Budapest IX., Tűzoltó utca 37-47, H-1094

Lecturers


Prof. Ádám, Veronika MD, PhD, DSci (ÁV)
Prof. Mandl, József MD, PhD, DSci (MJ)
Prof. Machovich, Raymund MD, PhD, DSci (MR)
Prof. Tretter, László MD, PhD, DSci (TL)
Csanády, László MD, PhD (CsL)
Kolev, Kraszimir MD, PhD, DSci (KK)
Komorowicz, Erzsébet MD, PhD, DSci (KE)
Törőcsik, Beáta MD, PhD, DSci (TB)

Lecture slides, seminars

Schedule of lectures

 

Week mm.dd
1. 02-06 Na+,K+ ATP-ase I The permeability of cell membranes, P-type ATP-ase. Structure of Na, K-ATP-ase  (ÁV)
02-08 Na+,K+ ATP-ase II Na, K-ATP-ase isoforms. Regulation. Secundary active transports. Na-H exchange (ÁV)
2. 02-13 Research Student's Conference
02-15 Chemical neurotransmission. Cholinergic neurotransmission. Biosynthesis of acetylcholine, receptors, acetylcholine esterase. Molecular mechanism of exocytosis (ÁV)
3. 02-20 Noradrenergic neurotransmission. Biosynthesis and metabolism of norepinephrine. Synaptical uptake (ÁV)
02-22 Molecular mechanisms of adrenergic, dopaminergic and serotoninergic neurotransmission (ÁV)
4. 02-27 NO: Regulatory role of NO. Nitric oxide synthase. Guanylate cyclase. Molecular effects of nitric oxide (ÁV) 
03-01 Glutamatergic neurotransmission. Synthesis, transporters, receptors. Biochemistry of Parkinson disease (ÁV)
5. 03-06 GABAergic neurotransmission (ÁV)
03-08 General properties of ion channels. Methods for studying ion channels. (CsL)
6. 03-13 Structure of the K+ channels. Methods for studiing ion channels. The molecular mechanism of gating and permeation. (CsL)
03-15 National-Holiday
7. 03-20 Biotransformation I (MJ)
03-22 Biotransformation II (MJ)
8. 04-03 Signaltransduction I (MJ)
04-05 Signaltransduction II (MJ
9. 04-08 Signaltransduction III (MJ (This lecture is held on Monday, at 08.00-09:10. Lecture Hall of the 1st Department of Obstetrics and Gynaecology 1085 Budapest, VIII. Baross utca 27.)

04-12 Haemostasis I. (KK) Pathobiochemistry of atherothrombosis and atherosclerosis. The role of cholesterol in the formation of atherosclerotic plaques. LDL oxidation and scavenger receptors. Risk factors of atherosclerosis related to cholesterol homeostasis (diabetes, hypertriglyceridemia). Biochemical background for prevention of atherosclerosis (Plant oils and alcohol consumpltion, execise).
10. 04-17 Haemostasis II: Initiation of blood coagulation - Protein C and thrombomodulin. Termination of blood coagulation: inhibitors (antithrombin - heparin, hirudin, TFPI). Alternative pathway of blood coagulation: Factor XII (MR)

04-19 Haemostasis III: Fibrinolysis. Degradation of fibrin (D and E fragments): fibrinolytic enzymes (plasmin, elastase). Fibrin substrates, D-dimers. Activation of plasminogen: Glu-plasminogen (native), conformational and proteolytical modifications. Plasminogen activators (tPA and confactors, uPA, streptokinase) Inhibitors of fibrinolytical enzymesa2-plasmin inhibitor, plasminogen activator inhibitor-1 (PAI-1). Regulation of plasminogen activation and fibrinolysis, TAFI. Functions of PMN and fibrinolysis. (MR)
11. 04-24 Haemostasis IV: Adhesion molecules. Cadherines, selectins, IgSF cellular molecules. Integrins. Platelets. Structure and function (adhesion, vWF and aggregation, fibrinogen) Activation, triggers (thrombin, collagen, PAF). Secondary activators (ADP, TXA2). Receptors (thrombin receptor). Activation, inhibitors. PGI2 and TXA2, platelet activation (MR)

04-26 Haemostasis V: The endothelium. Structure and hemostatic role. Procoagulant components. von Willebrand Factor (vWF). Anticoagulant components. NO, Endothelin, PAR1, ACE, MMP-9. Angiogenesis. Angiogenin and angiostatin. Thrombophylia. Anticoagulant therapy: Vitamin K antagonists, INR. Heparine. Hirudin. Aspirin and platelets. Plasminogen activators. Acute myocardial infarcts. Stroke. (MR)
12. 05-03 Signaltransduction IV: Therapeutic targeting of signal transduction pathways (TB)
13. 05-08 Signaltransduction V: Calcium signalling (TB)
05-10 Steroid hormons of adrenal cortex. Steroid hormon receptors.  Signaltransduction mechanism of steroid hormone receptors. Classical or non-genomical actions of steroid hormones. Biosynthesis of glucocorticoids, effect of cortisol, regulation of cortisol synthesis, CAH (congenital adrenal hyperplasia) (KE)
14. 05-15 Sexual hormons Biosynthesis of sexual hormones. The cyclic changes in the ovary, the cooperation of granolosa and theca interna cells. Placental progesterone and estradiol synthesis of  (KE)
05-17 Eicosanoid. prostaglandins, thromboxanes and leukotrienes. The cyclooxygenase and lipoxigenase pathway. Effect of eicosanoids: platelet aggregation, gastric mucosal protection, myometrial contractility, inflamation(KE)