Lectures

Tuesday 12:30-13:30
Thursday 08:00-09:10
.
Szent-Györgyi Albert lecture hall
EOK Building, Semmelweis University
Budapest IX., Tűzoltó utca 37-47 H-1094
.

Lecture slides

Week

mm-dd

Topic

 

 

Csala, Miklós M.D., Ph.D.,

01

09-10

Transformation of energy, group transfers in metabolism.

 

09-12

Biological oxidation. Role of mitochondria.

02

09-17

Glycolysis.

 

09-19

Formation of acetyl-CoA - pyruvate-dehydrogenase, fatty acid oxidation.

09-20

Citrate cycle. (FRIDAY, 17:30-18:40, Szent-Györgyi Albert lecture hall)

03

09-24

Terminal oxidation, oxidative phosphorylation.

 

 

Prof. Mandl, József, M.D., Ph.D., D. Sci.,

 

09-26

Gluconeogenesis. Glycogen metabolism.

04

10-01

Regulation of glycolysis and gluconeogenesis

 

10-03

Regulation of glycogen metabolism.

05

10-08

Regulation of blood glucose level

 

10-10

Diabetes Mellitus

06

10-15

Degradation and synthesis of various carbohydrates.

 

 

Prof. Ádám, Veronika, M.D., Ph.D., D. Sci.,

 

10-17

Metabolism of lipids - overview. Absorption of lipids.

07

10-24

Oxidation of fatty acids, ketone bodies.

08

10-29

Synthesis of fatty acids.

 

10-31

Lipoprotein metabolism.

 

 

Kolev, Kraszimir, M.D., Ph.D., D.Sci.,

09

11-05

Cholesterol homeostasis: sources of cholesterol in the cell, absorption of dietary cholesterol and inter-organ transport of cholesterol. Disposal of cholesterol and the role of bile acids.

 

11-07

Regulatory mechanisms in cholesterol homeostasis, metabolic receptors and their function in the liver, intestine and blood vessel wall. Biochemistry of atherosclerosis.

 

 

Prof. Sasvári, Mária M.D., Ph.D., D.Sci.,

10

11-12

The fate of the amino groups: transamination, deamination reactions and the urea cycle. The central role of glutamate in transdeamination. Glutamine and aspartate as amino group donors. Transport forms of ammonia, the role of glutamine and alanin. Clinical correlations: deficiencies of the urea cycle enzymes; origins and consequences of hyperammonemia.

 

11-14

Glucoplastic and ketoplastic amino acids: the metabolic intermediates produced from the carbon skeletons of amino acids. Clinical correlations: Phenylketonuria; Maple syrup urine diseas; Hiperhomocysteinemia.

11

11-19

Biosynthesis of nonessential amino acids. The methionin cycle and the „active methionine” as a methyl group donor. Formation and utilization of the tetrahydrofolate derivatives. Clinical correlations: origins and consequences of vitamin B12 deficiency.

 

 

Prof. Sasvári, Mária M.D., Ph.D., D.Sci.,

 

11-21

Metabolism of purine nucleotides: de novo synthesis and its regulation. Salvage reactions of purine bases. The purine nucleotide cycle. Catabolism of purine nucleotides. Clinical correlations: consequences of muscle adenylate deaminase deficiency; The Lesh-Nyen syndrome. Severe combined immunodeficiency (SCID). The biochemical background of gout.

12

11-26

Metabolism of pyrimidine nucleotides: de novo synthesis and its regulation. Orotic aciduria. Salvage reactions and catabolism of pyrimidine nucleosides. The ribonucleotide reductase reaction and its regulation. Synthesis of thymidylate. Clinical correlations: Nucleoside analogues in chemotherapy and the role of deoxynucleoside salvage reactions; the target enzyme of dihydrofolate analogues; the antibacterial effect of sulphonamides.

 

11-28

Metabolism of porphyrins and bile pigments: the synthesis and catabolism of heme. Clinical correlations: porphyrias and hyperbilirubinemias. Diagnostic value of the separate determination of direct and indirect bilirubin level in the blood.

 

 

Prof. Tretter, László M.D., Ph.D., D. Sci.,

13

12-03

Metabolism of red blood cells. Red blood cell enzymopathies.

 

12-05

Metabolism of skeletal and cardiac muscle, the role of SREBP, PPAR alpha and beta,

14

11-10

Intermediary metabolism of kidney, metabolism in kidney cortex and medulla.

 

11-12

Regulation of the well-fed state and starvation.