Topic list: Biotransformation, signaltransduction


  • Biotransformation: reactions of the first and second phase, biological significance, clinical aspects.
  • Reactions and significance of cytochrome P450 isoenzymes.
  • Conjugation of xenobiotics and of endogenous substrates.
  • Mechanisms of signal transduction processes mediated by cAMP. Formation, degradation of cAMP, PKA, cAMP and regulation of gene expression.
  • Signal transduction processes mediated by intracellular receptors: steroid, thyroid, retinoid receptors
  • Signal transduction processes connected to the changes of cytosolic Ca2+ concentration. Protein kinase C.
  • cGMP-mediated processes.
  • Synthesis of eicosanoids and their role in intercellular communication
  • Signal transduction of growth factors, MAP kinase pathway.
  • The signal transduction pathway initiated by the insulin receptor and its pathological implications.